In less than 5% of cases, genetics plays a more significant role by causing a hereditary breast-ovarian cancer syndrome.

About half of hereditary breast-ovarian cancer syndromes involve unknown genes.

The familial tendency to develop these cancers is called hereditary breast-ovarian cancer syndrome.

Harmful mutations in these genes produce a hereditary breast-ovarian cancer syndrome in affected families.

There is some evidence that breast cancers that arise in familial clusters, such as Hereditary breast-ovarian cancer syndrome, may have a dissimilar prognosis.

Certain variations of the BRCA2 gene increase risks for breast cancer as part of a hereditary breast-ovarian cancer syndrome.

Common examples of inherited cancer syndromes are hereditary breast-ovarian cancer syndrome and hereditary non-polyposis colon cancer (Lynch syndrome).

Testing for disease-causing mutations in the BRCA1 and BRCA2 genes, which are implicated in hereditary breast-ovarian cancer syndromes.

Goshen R, Chu W, Elit L, et al.: Is uterine papillary serous adenocarcinoma a manifestation of the hereditary breast-ovarian cancer syndrome?

Approximately half of men who develop breast cancer have a mutation in a BRCA gene or in one of the other genes associated with hereditary breast-ovarian cancer syndromes.

Hereditary breast-ovarian cancer syndrome (HBOC) is an autosomal dominant genetic disorder caused by genetic mutations of the BRCA1 and BRCA2 genes.

Hereditary breast-ovarian cancer syndromes (HBOC) produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual suffered from both, or several individuals in the families suffered from one or the other disease).