Zaitsev's rule

Zaitsev's rule helps to explain regioselectivity for this reaction type.

He worked on organic compounds and proposed Zaitsev's rule, which predicts the product composition of an elimination reaction.

When the substrate is asymmetric, regioselectivity is determined by Zaitsev's rule.

While effective at predicting the favored product for many elimination reactions, Zaitsev's rule is subject to many exceptions.

Zaitsev's rule applies in the elimination.

This is in direct contrast to normal elimination reactions where the more substituted, stable product is dominant (Zaitsev's rule).

Zaitsev's rule predicts that the major reaction product is the alkene with the more highly substituted (more stable) double bond.

The reaction, in general, obeys Zaitsev's Rule, which states that the most stable (usually the most substituted) alkene is formed.

While Zaitsev's paper was well referenced throughout the 20th century, it was not until the 1960s that textbooks began using the term "Zaitsev's rule."

Any discussion of Zaitsev's rule would be incomplete without mentioning Vladimir Vasilyevich Markovnikov.

Zaitsev's rule (or Saytseff's rule) is an empirical rule for predicting the favored alkene product(s) in elimination reactions.

More generally, Zaitsev's rule predicts that in an elimination reaction, the most stable alkene - typically the most substituted one - will be the favored product.

The stereochemistry of pericyclic reactions is governed by the Woodward-Hoffmann rules and that of many elimination reactions by the Zaitsev's rule.

Zaitsev's Rule was reported in 1875, and appeared just as his arch-nemesis, Markovnikov, (who had made a prediction which the rule contradicts) was taking the Chair at Moscow University.