NO synthase

The different forms of NO synthase have been classified as follows:

Baseline gall bladder pressure significantly increased after treatment with the NO synthase inhibitors.

The substrate of the NO synthase was able to reverse the effect of the inhibitor.

On the other hand, 3-hydroxyanthranilate inhibits both the expression and activity of NO synthase [ 39].

N-monomethyl-L-arginine is a more powerful antagonist of NO synthase.

Thus, the effect of NO synthase inhibitors may depend on the recent history of activity in the hippocampus.

These neurogenic responses could be inhibited, and indeed abolished by antagonists of NO synthase.

In neuroscience, methylene blue can also serve as a non-selective inhibitor of NO synthase.

NO synthase may refer to:

Production of NO is from L arginine via NO synthase.

The withdrawal of kynurenine from this flow route might undermine the levels of 3-hydroxyanthranilate sufficiently to release the restraints on NO synthase.

Also, the experiments performed in vitro clearly show that the effects of inhibition of NO synthase are independent of blood flow.

Finally, our data show that endotixin is able to induce a calcium independent NO synthase in guinea pig gall bladder tissue.

Nitric oxide is synthesised from L-arginine in a reaction catalysed by NO synthase.

By contrast, D-arginine did not reverse the pressor effects induced by the NO synthase inhibitors.

Furthermore, other laboratories, including our own, have not found a consistent block of LTP with NO synthase inhibitors.

Thus we designed the present experiments to investigate the effect of NO synthase inhibition on gall bladder muscular activity in vivo and in vitro.

Figure 2 shows the effect of inhibition of NO synthase on the response of the gall bladder to CCK-8.

These compounds model biological complexes such as cytochrome P450, NO synthase, and isopenicillin N synthase.

Additionally, supplementing the diet with additional L-arginine will decrease the amount of competition between arginase and NO synthase by providing extra substrate for each enzyme.

S-Ethylisothiouronium diethylphosphate is a specific inhibitor of inducible NO synthase on hepatic NO production level.

Administration of L-arginine, a substrate of NO synthase, reversed the effect of the inhibitors; however, the enantiomer D-arginine was ineffective.

Alternatively, NO could be produced on demand only, and it is conceivable that depolarisation makes calcium available for NO synthase activation within the presynpatic neuron.

Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress.

In patients with pulmonary arterial hypertension endothelial NO synthase, the enzyme that is responsible for the production of NO, is expressed to reduced levels.