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This in turn causes a loss of adhesion with acantholysis as a result.
The process leads to the loss of cellular connections (acantholysis) and ultimately blistering of the skin.
The pathologist looks for an intraepidermal vesicle caused by the breaking apart of epidermal cells (acantholysis).
The autoantibodies cause the junctions to break down and the keratinocytes to separate (acantholysis) giving rise to the formation of blisters.
When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes "unglued", a phenomenon called acantholysis.
As its name indicates, pemphigoid is similar in general appearance to pemphigus, but, unlike pemphigus, pemphigoid does not feature acantholysis.
Irregular areas of dekeratinized and desquamated filiform papillae (red in color) are surrounded by elevated whitish or yellow margins due to acantholysis and hyperkeratosis.
Intraepidermal neutrophilic IgA dermatosis is characterized histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis.
Adenoid squamous-cell carcinoma (also known as "Pseudoglandular squamous-cell carcinoma") is a cutaneous condition, a subtype of squamous-cell carcinoma, characterized by a tubular microscopic pattern and keratinocyte acantholysis.
A mutation on one copy of the gene causes only half of this necessary protein to be made and the cells of the skin do not adhere together properly due to malformation of intercellular desmosomes, causing acantholysis, blisters and rashes.