direct bilirubin

The diagnosis is narrowed down further by looking at the levels of direct bilirubin.

Only direct bilirubin appears in the urine.

Total and direct bilirubin are usually measured to screen for or to monitor liver or gallbladder problems.

The measurement of direct bilirubin depends on its reaction with diazosulfanilic acid to create azobilirubin.

If the bile ducts are blocked, direct bilirubin will build up, escape from the liver, and end up in the blood.

Increased direct bilirubin usually means that the biliary (liver secretion) ducts are obstructed.

Indirect bilirubin is fat-soluble and direct bilirubin is water-soluble.

Total serum bilirubin equals direct bilirubin plus indirect bilirubin.

Direct bilirubin dissolves in water (it is soluble) and is made by the liver from indirect bilirubin.

Direct bilirubin (conjugated bilirubin)

Likewise, urinary TBARS were not correlated with direct bilirubin (Fig.

If direct bilirubin is elevated, then the liver is conjugating bilirubin normally, but is not able to excrete it.

This "conjugated" (attached) bilirubin is called direct bilirubin; unconjugated bilirubin is called indirect bilirubin.

Total and direct bilirubin levels can be measured from the blood, but indirect bilirubin is calculated from the total and direct bilirubin.

Statistical analysis Direct bilirubin, ALT, AST, alkaline phosphatase, and urinary TBARS values were not normally distributed.

Total bilirubin is now often measured by the 2,5-dichlorophenyldiazonium (DPD) method, and direct bilirubin is often measured by the method of Jendrassik and Grof.

Despite longer TPN courses and elevated serum transaminases, infants with cholestasis or elevated serum direct bilirubin did not display elevated urinary TBARS.

Furthermore, direct bilirubin tends to overestimate conjugated bilirubin levels due to unconjugated bilirubin that has reacted with diazosulfanilic acid, leading to increased azobilirubin levels (and increased direct bilirubin).

Crigler-Najjar syndrome Erythroblastosis fetalis Gilbert's disease Healing of a large hematoma (bleeding under the skin) Hemolytic anemia Hemolytic disease of the newborn Physiological jaundice (normal in newborns) Sickle cell anemia Transfusion reaction Pernicious anemia Increased direct bilirubin may indicate: