distribution coefficient

Where K is called the distribution coefficient or the partition coefficient.

D and λ are the distribution coefficients.

Retention factors are proportional to distribution coefficients.

The distribution coefficient (Log D) is the correct descriptor for ionizable systems.

The ratio of concentrations in the two solvents is known as a partition coefficient or distribution coefficient.

Therefore the ideal distribution coefficient for a drug is usually intermediate (not too hydrophobic nor too hydrophilic).

The term is often confused with partition coefficient or distribution coefficient, and is often represented by K.

The relevant distribution coefficients for common POPs are several orders of magnitude in favor of the plastic medium.

For example, the distribution coefficient for benzoic acid in benzene and water increases with increasing concentrations in the two layers.

Hence the hydrophobicity of a compound (as measured by its distribution coefficient) is a major determinant of how drug-like it is.

Hence both the partition and distribution coefficient are measures of how hydrophilic ("water-loving") or hydrophobic ("water-fearing") a chemical substance is.

Many other industries take into account distribution coefficients for example in the formulation of make-up, topical ointments, dyes, hair colors and many other consumer products.

Partition chromatography is based on differences in capacity factor, k, and distribution coefficient, Kd, of the analytes using liquid stationary and mobile liquid phase.

The distribution coefficient K is the ratio of the soil's radioactivity (Bq g) to that of the soil water (Bq ml).

The distribution coefficient is the ratio of the sum of the concentrations of all forms of the compound (ionized plus un-ionized) in each of the two phases.

A selectivity factor is defined as the ratio of distribution coefficients, which describe the equilibrium distribution of an analyte between the stationary phase and the mobile phase.

Distribution coefficients may be measured or predicted for compounds currently causing problems or with foresight to gauge the structural modifications necessary to make a compound environmentally more friendly in the research phase.

Hydrologists primarily concerned with the physical nature of mass transport assumed relatively simple reaction formulations, such as linear distribution coefficients or linear decay terms, which could be added to the advection-dispersion equation.

Its distribution coefficient between water and the tissue of the Hunter's species was very small-it had to be, to be as quick a trap, as it was-but it was far from zero.

K is the distribution coefficient or K factor, defined as the ratio of mole fraction in the vapor phase to the mole fraction in the liquid phase at equilibrium.

Comparison of the effect of alpha and gamma radiolysis of a cation exchanger on the distribution coefficient, separation factor, and plate heights [In German], J. Radioanal.

For measurements of distribution coefficient, the pH of the aqueous phase is buffered to a specific value such that the pH is not significantly perturbed by the introduction of the compound.

In the context of pharmacokinetics (what the body does to a drug), the distribution coefficient has a strong influence on ADME properties (Absorption, Distribution, Metabolism, and Excretion) of the drug.

Furthermore, the lipid solubility of the unionized species is slight as shown by its low logP value [log(10) of the distribution coefficient of the unionized form between octanol and water] of -1.43.

Where equilibrium sorption is described by a linear distribution coefficient, for example, the sorbing solute's velocity is retarded relative to that of a nonreactive tracer; the relative velocities can be described with a retardation factor.