epistasis

Two central interests of Wade's research program are population structure and epistasis.

The word epistasis is also used for genetic interaction in some contexts.

This is an effect called epistasis, and is not unusual.

We used this optimizationprocedure to analyze 100 data sets of each epistasis model.

There is little statistical evidence for contributions from overdominance and epistasis.

This does not take into account the effects of epistasis, which would probably increase the number of related genes.

The ubiquitous nature of epistasis in determining susceptibility to common human diseases.

This relationship between number of mutations and fitness is known as synergistic epistasis.

This interaction between genes is called epistasis, with the second gene epistatic to the first.

Note thatthe optimal architecture varied for each of the epistasis models.

This type of genetic interaction is called epistasis.

The epistasis parameter β, on the other hand, lies almost entirely below unity.

This is precisely the pattern of excess antagonistic epistasis that demands an explanation.

An explanation for epistasis is an important manifestation of Garrod's research, albeit indirectly.

In synergystic epistasis, each additional mutation has increasing negative impact on fitness.

Epistasis occurs when the expression of one gene is modified by another gene.

While the method has been particularly developed for examining epistasis in S. cerevisiae, it could be applied to other model organisms as well.

Supplementary epistasis occurs when two loci affect the same phenotype.

To test epistasis relationships between these mutants, a double mutant was constructed (see Methods).

This phenomenon is referred to as recessive epistasis.

Genetic interactions (epistasis) can often confound simple interpretations of such "knockout" studies.

This systematic approach to studying epistasis on a genome wide scale has significant implications for functional genomics.

Over time, sexual populations move towards more negative epistasis, or the lowering of fitness by two interacting alleles.

We simulated 100data sets of each epistasis model with two functional SNPs.