kinetochore

Zwint-1 is clearly involved in kinetochore function although an exact role is not known.

The kinetochore is critical to ensuring duplication without loss or damage to the genetic material.

Even a single unattached kinetochore can maintain the spindle checkpoint.

However, not all the MTs in the spindle attach to one kinetochore.

During this searching process, a microtubule may encounter and capture a chromosome through the kinetochore.

There are two groups of +TIPs with kinetochore functions.

During mitosis, each sister chromatid forming the complete chromosome has its own kinetochore.

Only one unattached kinetochore is required to fuel a response that ultimately blocks cell cycle progression.

They are defined as any microtubule originating from the centrosome which does not connect to a kinetochore.

Another regulator of checkpoint activation is kinetochore tension.

Microtubules that attach to the kinetochores are known as kinetochore microtubules.

MTs are highly dynamic structures, whose behavior is integrated with kinetochore function to control chromosome movement and segregation.

Together with the constitutive components, these proteins seem to organize the nuclear core of the inner and outer structures in the kinetochore.

Once they bind a kinetochore, they are stabilized and their dynamics are reduced.

Numerous kinetochore targets of Aurora kinases have been determined in organisms ranging from yeast to man.

During metaphase, the kinetochore microtubules connect to the centromere.

Although the kinetochore structure and function are not fully understood, it is known that it contains some form of molecular motor.

In the fishing pole analogy, the kinetochore would be the "hook" that catches a sister chromatid or "fish".

It plays a role in the localization of kinetochore of BUB1.

During mitosis, spindle fibers attach to the centromere via the kinetochore.

Very few mitochondria are retained and the nucleus enlarges with a kinetochore complex attached to the nuclear envelope.

This second attachment further stabilizes kinetochore attachment to the mitotic spindle.

Merotelic attachment occurs when one kinetochore is attached to both mitotic spindle poles.

DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes.

"Holocentric" organisms, such as nematodes and some plants, assemble a kinetochore along the entire length of a chromosome.