phosphogluconate dehydrogenase

It is formed by 6-phosphogluconolactonase, and acted upon by phosphogluconate dehydrogenase to produce ribulose 5-phosphate.

Phosphogluconate dehydrogenase is an enzyme in the pentose phosphate pathway.

Recently, phosphogluconate dehydrogenase has been posited as a potential drug target for African sleeping sickness (trypanosomiasis).

A third fusion event occurred between glucose 6-phosphate dehydrogenase with phosphogluconate dehydrogenase in a diatom species (Phaeodactylum tricornutum).

It is formed by phosphogluconate dehydrogenase, and it can be acted upon by phosphopentose isomerase and phosphopentose epimerase.

Several studies have linked oxidative stress to diseases such as Alzheimer's disease, as well as cancer, These studies have found phosphogluconate dehydrogenase activity to be up-regulated, both in tumor cells and in relevant cortical regions of Alzheimer's patient brains, most likely as a compensatory reaction to highly oxidative environments.