pneumocyte

The target cell for P. carinii is believed to be the type I pneumocyte.

After contact with the type I pneumocyte, P. carinii trophozoites anchor themselves to the host cell.

Germination occurs both extracellularly or in type II pneumocyte endosomes containing conidia.

Type I pneumocyte (Squamous Alveolar) cells that form the structure of an alveolar wall.

Specifically, sections were graded from 0 to 4 for chronic inflammation, granulation tissue, type II pneumocyte hyperplasia, dense fibrosis, and pulmonary-vessel-wall changes.

In the latter study, we also noted prominent type II pneumocyte expression of ET-1 in a small number of patients with pulmonary hypertension and fibrosis.

The pathology of CFA is characterised by inflammation, type II pneumocyte and fibroblastic proliferation, and collagen deposition.

In non-mucinous BAC, neither Clara cell nor Type II pneumocyte differentiation appears to affect survival or prognosis.

Up to 90% of surfactant DPPC (dipalmitoyl phosphatidylcholine) is recycled from the alveolar space back into the type II pneumocyte.

In addition, ET-1-IR grades for all patients correlated significantly with histological parameters of disease activity - ie, presence of granulation tissue and type II pneumocyte proliferation.

Type II pneumocyte (Great Alveolar) cells that secrete pulmonary surfactant to lower the surface tension of water and allows the membrane to separate, thereby increasing the capability to exchange gases.

Nonmucinous BAC is thought to derive from a transformed cell in the distal airways and terminal respiratory units, and often shows features of Clara cell or Type II pneumocyte differentiation.

The protein encoded by this gene (SP-A2) is primarily synthesized in lung alveolar type II cells (see type II pneumocyte), as part of a complex of lipids and proteins known as pulmonary surfactant.

Alveolar type II pneumocytes and airways epithelial cells were the main sites of ET-1 expression, and the magnitude of immunostaining correlated well with the extent of type II pneumocyte proliferation and adjacent granulation tissue.

To analyse the correlations further, we summed the histology grades (young granulation tissue and type II pneumocyte proliferation) and correlated this with the summed airway epithelium and type II pneumocyte staining.