proopiomelanocortin

Proopiomelanocortin has been shown to interact with melanocortin 4 receptor.

Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity.

Examples include proinsulin and proopiomelanocortin.

Ontogenesis of proopiomelanocortin and its processing to beta-endorphin by the fetal and neonatal rat brain.

The nucleotide sequence of the human gene for proopiomelanocortin (POMC) was characterized in 1980.

Normal variation in leptin levels is associated with polymorphisms in the proopiomelanocortin gene, POMC.

A Melanotroph (or melanotrope) is a cell in the pituitary gland which generates melanocyte-stimulating hormone from its precursor Proopiomelanocortin.

These results taken together prove the existence of two distinct mRNAs coding for proopiomelanocortin in the porcine pituitary intermediate lobe.

The Proopiomelanocortin gene (POMC) is expressed in the hypothalamus, in the pituitary gland.

The peptides with opioid activity that are derived from proopiomelanocortin comprise the class of endogenous opioid peptides called "endorphins".

Activation of these dopamine receptors leads to the inhibition of proopiomelanocortin (POMC) production from these cells.

This process is under hormonal control, including the MSH and ACTH peptides that are produced from the precursor proopiomelanocortin.

The activation of 5-HT receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety.

Effects of leptin and corticosterone on the expression of corticotropin- releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse.

N-Terminal Peptide of Proopiomelanocortin (NPP, or pro-γ-MSH)

The proopiomelanocortin gene (POMC) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into enkephalin.

PCSK1 and PCSK2 differentially cleave proopiomelanocortin and they act together to process proinsulin and proglucagon in pancreatic islets.

This occurs because MSH and ACTH share the same precursor molecule, proopiomelanocortin (POMC).

It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC).

We have transiently expressed the yeast KEX2 gene together with the proopiomelanocortin (POMC) cDNA in COS-1 cells.

It is generated as a proteolyic cleavage product from ACTH (1-13), which is in turn a cleavage product of proopiomelanocortin (POMC).

It is hypothesized that these elevations are due to disturbances in the complex neuronal network that includes the neuropeptide Y (NPY) and proopiomelanocortin (POMC) pathways.

An accumulation of evidence implicates leptin, insulin, glucocorticoids, proopiomelanocortin (POMC), and neuropeptide Y (NPY) interactions as being integral to metabolic control associated with neuroendocrine-endocrine functioning.

POMC Control: Understanding how the Gene Proopiomelanocortin (POMC) Regulates Metabolism In most developed countries including Canada, nearly half of all adults are overweight.

Coming to Canada from USA Research involves Using transgenic technology and unique strains of mice to learn how the gene proopiomelanocortin controls blood sugar and body weight in diabetes and during aging.