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It belongs to the family of drugs called ribonucleotide reductase inhibitors.
This conversion is catalysed by ribonucleotide reductase (see figure).
Unlike other glutaredoxins, glutaredoxin 2 (Grx2) cannot reduce ribonucleotide reductase.
Deoxyribose is generated from ribose 5-phosphate by enzymes called ribonucleotide reductases.
The reduction of ribonucleotides to deoxyribonucleotides is catalyzed by ribonucleotide reductase.
This gene encodes one of two non-identical subunits for ribonucleotide reductase.
Simultaneously deoxyribosyl analogs are formed, via the enzyme ribonucleotide reductase.
The Stirrup protein domain is found in prokaryotic protein ribonucleotide reductases.
It is the ribonucleotide of hypoxanthine and the first nucleotide formed during the synthesis of purine.
Hydrolysis of the phosphate bonds generates the ribonucleotide guanine mono-phosphate and a modified 2-pyridone.
In biochemistry, a ribonucleotide or ribotide is a nucleotide containing D-ribose as its pentose component.
Tezacitabine is a ribonucleotide reductase inhibitor.
Another target of gemcitabine is the enzyme ribonucleotide reductase (RNR).
Glycineamide ribonucleotide (or GAR) is an intermediate in the synthesis of purines.
Also, the interactions with the protomers resembles ribonucleotide reductase R2 protein dimer interaction, resembling a heart.
This was the ribonucleotide IMP.
A hydrophilic core between four central helices (yellow ribbon) in the R2 subunit after the removal of iron from ribonucleotide reductase.
Ribose aminooxazoline can then react with cyanoacetylene in a mild and highly efficient manner to give the alpha cytidine ribonucleotide.
The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates.
Glutaredoxins function as electron carriers in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.
Triapine, a ribonucleotide reductase inhibitor, is being evaluated in clinical trials sponsored by the National Cancer Institute.
Another ATP molecule causes an intermolecular reaction that produces an imidazole ring (5-aminoimidazole ribonucleotide).
Subsequently, the reaction involves the elimination of one water molecule from carbon C-2' of the ribonucleotide, catalyzed by Cys225 and Glu441.
The mRNA carries genetic information encoded as a ribonucleotide sequence from the chromosomes to the ribosomes.
Human C6orf58 has been reported to interact with the enzyme ribonucleotide reductase as encoded by the vaccinia virus through a yeast two-hybrid screen.