sirtuins
Sir2 proteins

The mechanism has been proposed as a change in the activity of the sirtuins.

Several studies have explored the role sirtuins played in cocaine-seeking behavior.

In their view, it is not even clear if the sirtuins should be activated or inhibited for best effect.

Yeast Sir2 and some, but not all, sirtuins are protein deacetylases.

The genes encode proteins called sirtuins, which are found in both plants and animals.

However, non-histone proteins can be deacetylated by sirtuins as well.

I think the drugs that aim at sirtuins, for example, will be tested initially for a particular disease, say, diabetes.

The next step, which is a difficult one, would be to develop drugs that stimulate the sirtuins, bolstering the repair of damage in cells.

These activities of sirtuins are particularly interesting because of their importance in the regulation of aging.

Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes.

The ongoing saga of sirtuins and aging.

Seven sirtuins are known in mammals.

In addition to controlling metabolism at the transcriptional level, sirtuins also directly control the activity of metabolic enzymes.

Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuins have been proposed as a chemotherapeutic target for type II diabetes mellitus.

The sirtuins could also improve memory, a fact often on the mind of Dr. Sinclair, who has been taking resveratrol for three years.

One major uncertainty is whether resveratrol in the mice experiments even acts through sirtuins, supporting the theory, or in some other way.

The lysine molecule can be deacetylated by another class of enzyme called sirtuins, to be more specific, Sirt3.

Substrate specific activation of sirtuins by resveratrol.

Dr. Westphal, the company's chief executive, has no practical interest in the longevity-promoting effects of sirtuins and caloric restriction.

However, unlike sirtuins, AcuC does not require NAD+ as a cosubstrate.

Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

The sirtuins mainly seem to be involved in regulating transcription through deacetylating histones and altering nucleosome structure.

Sirtris has also developed several other chemicals that activate sirtuins at doses one-thousandth that of resveratrol.

The protein enzymes made by the genes are known as sirtuins, a word biologists have derived, with a simplicity likely to make etymologists wince, from sir-2.

Sirtuin or Sir2 proteins are a class of proteins that possess either mono-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity.