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It is for treating skin and soft tissue infections.
In skin and soft tissue infections, 4 mg/kg daptomycin is given intravenously once daily.
The drug is licenced for the treatment of skin and soft tissue infections as well as intra-abdominal infections.
Cephalosporins are commonly used in humans to treat pneumonia as well as to treat skin and soft tissue infections.
It has been shown to be statistically noninferior to the combination of vancomycin and ceftazidime for the treatment of skin and soft tissue infections.
Its use is approved for upper and lower RTI, H. pylori, and, skin and soft tissue infections.
The manufacturer advises against the use of linezolid for community-acquired pneumonia or uncomplicated skin and soft tissue infections caused by MRSA.
In Taiwan, ST59 strains, some of which are resistant to many non-beta-lactam antibiotics, have arisen as common causes of skin and soft tissue infections in the community.
Subsequently reports of a massive rise in skin and soft tissue infections were reported by the CDC in the Los Angeles County Jail system in 2001, and this has continued.
Skin and Soft Tissue Infections - Furuncles, carbuncles, cellulitis, paronychia, impetigo contagiosa, diabetic foot ulcers and abscesses caused by Staphylococcus aureus and Streptococcus pyogenes.
Iclaprim (INN), codenamed AR-100 and RO-48-2622, is a diaminopyrimidine dihydrofolate reductase inhibitor being developed for the treatment of complicated skin and soft tissue infections caused by antibiotic-resistant bacteria.
In Phase III clinical trials, intravenously-administered iclaprim was found to be as effective as and better tolerated than linezolid in people with skin and soft tissue infections, many caused by methicillin-resistant Staphylococcus aureus (MRSA).
A study in Detroit, Michigan compared 53 patients treated suspected MRSA skin or soft tissue infection with daptomycin against vancomycin, has been shown to result in faster recovery from skin and soft tissue infections (4 days versus 7 days).
The two MRSA clones in the United States most closely associated with community outbreaks, USA400 (MW2 strain, ST1 lineage) and USA300, often contain Panton-Valentine leukocidin (PVL) genes and, more frequently, have been associated with skin and soft tissue infections.
It can also be useful in skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA); many strains of MRSA are still susceptible to clindamycin; however, in the United States spreading from the West Coast eastwards, MRSA is becoming increasingly resistant.